2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113653
    GSK2041706A 1032824-43-3 98%
    GSK2041706A (GSK706) is a potent G protein-coupled receptor 119 (GPR119) agonist. GSK2041706A can be used for the research of type 2 diabetes.
    GSK2041706A
  • HY-113724
    S-8666 103968-87-2 98%
    S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees).
    S-8666
  • HY-113738
    ADN 138 99434-90-9 98%
    ADN-138 is an aldose reductase inhibitor. ADN-138 reduces sorbitol levels in diabetic nerves and results in significant increases in MNCV and Na+, K+-ATPase in the nerves. ADN-138 can be used in the research of diabetic nerve complications.
    ADN 138
  • HY-113767
    Momordin II 95851-41-5 98%
    Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity.
    Momordin II
  • HY-113777
    22-HDHA 90780-46-4 98%
    22-HDHA (22-Hydroxy Docosahexaenoic acid) is an oxidation product of docosahexaenoic acid. In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans.
    22-HDHA
  • HY-113781
    Ractopamine 97825-25-7 98%
    Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs.
    Ractopamine
  • HY-113820
    AZD4619 549494-39-5 98%
    AZD4619 is an orally active, selective peroxisome proliferator-activated receptor α (PPARα) agonist. AZD4619 increases alanine aminotransferase 1 (ALT1) protein expression in a dose-dependent manner in human, but not in rat primary hepatocytes. AZD4619 is a lipid-lowering drug.
    AZD4619
  • HY-113840
    Sumarotene 105687-93-2 98%
    Sumarotene (Ro 14-9706), an arotinoid methyl sulfone, is a potent dermatologic agent for the repair of photodamage, antikeratinization, and antiproliferation. Sumarotene exhibits in rats a prolactin-suppressive activity which affects lactation.
    Sumarotene
  • HY-113879
    18-Carboxy dinor Leukotriene B4 102674-12-4 98%
    18-Carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.
    18-Carboxy dinor Leukotriene B4
  • HY-113906
    GSK1614343 1092076-04-4 98%
    GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC50 value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models.
    GSK1614343
  • HY-113918
    SW-106 98%
    SW-106 is a selective antagonist of parathyroid hormone/parathyroid hormone-related peptide receptor (PPR) and PTHR1, with an IC50 value of 0.99 μM against PPR. SW-106 antagonizes cAMP responses. SW-106 can be used in the research of osteoporosis.
    SW-106
  • HY-114159
    GGTI-2166 478908-51-9 98%
    GGTI-2166 is a geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2166 blocks geranylgeranylation modification of target proteins. GGTI-2166 inhibits RANKL- or TNF-α-induced pre-osteoclast formation and TRAP activity. GGTI-2166 is applicable to research on osteoclast differentiation.
    GGTI-2166
  • HY-114184
    MK-8245 analog 1030612-87-3 98%
    MK-8245 analog (compound 6) is a potent stearoyl-CoA desaturase (SCD) inhibitor with an IC50 of 7 nM for rat SCD. MK-8245 analog has antidiabetic and antidyslipidemic effects.
    MK-8245 analog
  • HY-114232
    BVT-74316 917095-86-4 98%
    BVT-74316 is a 5-HT6 receptor antagonist. BVT-74316 can reduce food intake and bodyweight gain in rodent models. BVT-74316 can be used for the research of metabolic disease, such as obesity.
    BVT-74316
  • HY-114293
    Acetyl coenzyme A 72-89-9 98%
    Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis.
    Acetyl coenzyme A
  • HY-114426
    AT-1002 835872-35-0 98%
    AT-1002, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.
    AT-1002
  • HY-114517
    3-Acetyl-2,5-dimethylfuran 10599-70-9 99.73%
    3-Acetyl-2,5-dimethylfuran is a flavoring agent exhibiting genotoxic potential in vitro assays.
    3-Acetyl-2,5-dimethylfuran
  • HY-114559
    DNJNAc 105265-96-1 99.37%
    DNJNAc is an inhibitor of β-N-acetylglucosaminidases with a KiM value of 7 μM.
    DNJNAc
  • HY-114567
    GW780056X 1093294-48-4 98%
    GW780056X is a CDK12 inhibitor. GW780056X decreases nuclear foci count in DM1 cells. GW780056X can be used for the research of myotonic dystrophy type 1.
    GW780056X
  • HY-114598
    WAY-123783 152595-59-0 98%
    WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED50 = 9.85 mg/kg). WAY-123783 can be used for the research of metabolic disease, such as diabetes.
    WAY-123783
Cat. No. Product Name / Synonyms Application Reactivity